“Alchemy is woven into every aspect of the All Souls story from the very beginning, even down to the timings. The action of A Discovery of Witches takes place over forty days and is purposely structured to mirror the forty days of an alchemical experiment. Forty was a significant number in alchemy, as Mary Sidney pointed out to Diana when they were working in her laboratory. Mary was delighted when her own experiment with the arbor Dianae took exactly forty days to complete, ‘just as the sages promised.’”
Deborah Harkness, The World of All Souls