I'd adore someone who knows the casts better than me to imagine a campaign swap. Like, Vox Machina dealing with the war and Somnoven. Mighty Nein dealing with the Ruby Vanguard. Bells Hells fighting the Chroma Conclave and Vecna.
The Bell's Hells might function better against a present threat against Emon; it's less morally divisive. Conversely, the shorter timeline would probably fuck up the Mighty Nein, though they do have more religious characters; there'd be less conflict there at least.