Hey Shrink! I was trying to figure out what medications my bipolar character should take, and I noticed that there are a bunch of epilepsy meds listed! What gives??
Weirdly enough, that’s because the bipolar and epilepsy are actually kinda similar! Basically, we think they’re both related to instability in the neurons in your brain.
In epilepsy, the neurons will sometimes suddenly all go into overdrive in a relatively short amount of time (ie minutes).
In bipolar, we think that the neurons go through phases of increased and decreased activity compared to baseline. The fluctuations in bipolar are nowhere near the intensity seen in epilepsy, but they’re much longer term (ie weeks-months).
Anticonvulsants (also known as neuromodulators or mood stabilizers) work by keeping the neurons from getting too far away from their level of normal activity - whether it’s the sudden spikes from epilepsy or the long-term bipolar cycles.
Note - These are all currently just theories. We’re still not 100% sure exactly how this actually works. Brains are very complicated.
We don’t quite know how lithium, one of the oldest treatments for bipolar, works and it’s been in use for centuries
Yep! It’s one of the mysteries of psychopharmacology I’d really like to see solved.
[Image description: A tumblr reply from scix-in-the-back-row stating: “Centuries?????”]
Technically, yes. Lithium was first used to treat mania as early as the 1870s. However, it fell out of fashion for a while until the 1950s. [Source]