skye potentially being the inspiration rune is such a sick theory because she was in fact the only scientist in that lab who was willing to actually sacrifice her life's work to save others.. her nervous excitement while she's about to share months of studies with her mentor who btw "inspires everything she does" (like hmmm okay), her notebook (coincidentally blue & gold) held close to her heart as she practices what to say ..but then she walks on viktor getting swallowed by the hexcore and doesn't think twice before jumping to his rescue.
and maybe the hexcore felt that. saw her sacrifice. the no hesitation. the purity of her heart. saw the countless hours she spent researching a way to bring to life the original dream both jayce and viktor failed to deliver. and captured her soul for the greater scheme. she was the missing piece, the footprint needed to guide viktor and help him wake up the arcane.