Hey friends! It's COMICS TRIVIA TIME!
Question: What is the story behind the "Wanna make something of it?" cover of G4 My Little Pony comic #10?
Answer: It is a homage to the very well-known comic book cover of the 80s series "Justice League International"! (Well, actually the book was just called "Justice League" at that point, but let's not nitpick.)
In an era when comic books were increasingly grimdark, Justice League International was light-hearted, not afraid to explore relationships and emotions of superheroes rather than just "punch bam zowie", and was just plain funny. In other words it has a lot in common with G4 MLP!
Most of the characters were second-stringers (i.e. not well-known like the Flash or Superman), aside from Batman. So the further homage/joke with the MLP cover is that the ponies on it are all background ponies. Wanna make somethin' of it?
I've also included a recent Transformers comic cover, just because I like it and to show that this cover has been homaged a hundred thousand times, seriously.