So sometime after the war when Draco is a healer he is working with someone and they mention jokingly how Draco is an only child and Draco reveals that he actually has 3 dead sisters:
Ron: Classic only-child thinking
Draco: . . . . I'm not an only-child actually
Ron: I mean not anymore, but you were most your life
Draco: . . . . Kinda I had and older sister and two younger ones before
Ron: I’m - I
Draco: Lucrezia died after a battle with dragon pox, and Cassie and Drew got caught in some muggle conflict in Belfast. My mother barely survived it herself. To be honest a part of her died too. A part of all of us did.