if you have not thrown low dose naltrexone at it you have not tried everything. I am like a "have you tried weed" guy but for low dose naltrexone
chronic pain, chronic fatigue, brain fog, long covid, feeling like shit physically, feeling like shit mentally: LDN makes your body heal faster and produce more good™ chemicals. how it works depends on you because you are gaslighting your body to work better by making it think some receptors are broken. this is a disease-modifying treatment
naltrexone, even at a high dose, is extremely safe. and most side effects with LDN are from fillers used in compounding. in which case you ask for no fillers/for someone with chemical sensitivity.
I truly believe that there needs to be more funding to examine the effects of LDN on just about every chronic and terminal condition.
low dose naltrexone was discovered during the AIDS crisis. many people got HIV from drugs. those patients were put on naltrexone, because naltrexone at a high dose is used to treat drug addiction. and you know what doctors discovered? patients on naltrexone got less cancer compared to those not on naltrexone. and then they worked backwards from there. (DO NOT USE NALTREXONE AS A PRIMARY TREATMENT FOR CANCER.)
the main detriment to LDN is the reputation of naltrexone. at 100mg-150mg, it treats things like heroin addiction. at 4.5mg, it treats chronic illness and can benefit countless different health issues. because it just makes your body work better! it might not be a cure, but comparing the risks to the benefits? barely anything else even gets close. the second main detriment to LDN is that it can take months to work, but once it kicks in, it can really really change lives for the better.
LDN is genuinely a miracle medicine to me. I will never shut up about it.
this information is from dysautonomia international conferences, and I am not sure how many of the LDN-focused presentations are public now, but there are a ton of groups dedicated to LDN these days.
a little more information here:
naltrexone turns off opioid receptors and helps stop people from dying of drug withdrawal.
at a low dose, naltrexone only turns off a few receptors. the body then thinks, OH SHIT! SOMETHING IS BROKEN! WE NEED TO HEAL FASTER AND MAKE MORE GOOD CHEMICALS
this can mean that people on low dose naltrexone might require a slightly higher dose of opioids for pain, but LDN can also just stop the pain from happening to begin with.
LDN is safe to stop before surgeries and medical procedures. it does not have withdrawal, it just stops doing the good things when you stop taking it.
comparing that to the dozens of medicines I have been on for pain and sleep and all sorts of shit, no pill has ever compared to LDN. and I am not the only one.
LDN is gentle and effective. it may not work for everyone, and sometimes people need to go up to ~12mg instead of 4.5mg, but in terms of things that are not going to give you a miserable withdrawal if you hate it AND might change your life, LDN fucking rocks
LDN is sort of a niche treatment (FOR NOW), but the good news is you do not necessarily need to find a local doctor who knows about LDN to get LDN. a lot of people (depending on local laws and availability) buy naltrexone online and compound it themselves or go through an online pharmacy like agelessRX in the US where a doctor walks you through LDN and prescribes it through a virtual appointment and ships it to you. I have heard great things about agelessRX for LDN.
if you compound it yourself, just keep in mind 4.5mg of naltrexone is such a small amount of stuff that you need a mortar and pestle and an oral syringe to dose it.
even better, the prices you see are not for low dose naltrexone! I think you saw the price for 30 days of 50mg naltrexone. which is a total of 1,500mg.
if you compound it yourself, that is actually around a year's worth of low dose naltrexone! it does not last very long once compounded, so you will need to do it a few times a month, but if you can do it yourself, yeah it is super cheap.
to get it already compounded it costs around $50 USD a month in the US.
edit: agelessRX has it compounded for $35/month or $105/quarter!