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Biomedical Ephemera, or: A Frog for Your Boils

@biomedicalephemera / biomedicalephemera.tumblr.com

A blog for all biological and medical ephemera, from the age of Abraham through the era of medical quackery and cure-all nostrums. Featuring illustrations, history, and totally useless trivia from the diverse realms of nature and medicine. Buy me a coffee so I can stay up and keep the lights on around here!
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Osteomyeltis of the femur, as a result of scarlet fever

Osteomyelitis is an intensely painful, often disastrous infection of the bone, which can have grave consequences. This case was the sequelae of a case of scarlet fever (a body-wide rash caused by strep throat), and resulted in amputation of the limb. This patient survived, but a large percentage of patients did not. Prior to antibiotics, many who contracted osteomyelitis (due to scarlet fever or other reasons) developed severe bacteremia (bacteria in the bloodstream), which often progressed to sepsis and death.

Think you have strep throat? See a doctor!

An American Text-Book of Surgery, for Practitioners and Students. Ed. William W. Keen & J. William White, 1899.

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Inevitabile Fatum - “Inescapable End”

These figures display the major bones of the human skull and cervical spine.

Though Andreas Vesalius was known as the first European physician to disregard the Galenic model of anatomy (based largely upon the bodies of other primates and not humans) and revolutionize our knowledge of the human form, Johann Dryander had already dissected and illustrated the human skull and brain twice, before Vesalius even came out with his first publication.

Vesalius performed most of his work in Padua, Italy, while Dryander lived and practiced in Marburg, Germany.

Anatomiae, hoc est, corporis humani dissectionis pars prior. Johann Dryander, 1537.

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Bones and Muscles of the Thigh and Leg

Clorion appears to have been Martha Chase Owen, the wife of Richard Owen, who was the son of the founder of the settlement of Harmonie/New Harmony, Indiana. She first arrived in the settlement with her first husband, Dr. Thomas Chase, who was an artist and a chemist.

After a year of turmoil and being turned out of her own house, Dr. Chase confronted his wife’s friend Richard Owen, who’d been walking around town with Martha....

[Anatomical Illustrations taken from The Domestic Physician]. Clorion, 1830. Via Historical Anatomies on the Web.

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Bones and muscles of the thigh and leg

For decades, the illustrations of “Clorionhad no definitive artist. Many accomplished medical artists had resided in New Harmony/Harmonie, Indiana, during the period where the illustrations were made, but it was unclear who had truly authored them.

[Anatomical Illustrations taken from The Domestic Physician]. Clorion, 1830. Via Historical Anatomies on the Web.

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Inevitabile Fatum - “Inescapable End”

These figures display the major bones of the human skull and cervical spine.

Though Andreas Vesalius was known as the first European physician to disregard the Galenic model of anatomy (based largely upon the bodies of other primates and not humans) and revolutionize our knowledge of the human form, Johann Dryander had already dissected and illustrated the human skull and brain twice, before Vesalius even came out with his first publication.

Vesalius performed most of his work in Padua, Italy, while Dryander lived and practiced in Marburg, Germany.

Anatomiae, hoc est, corporis humani dissectionis pars prior. Johann Dryander, 1537.

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Bones of the human hand and wrist

At birth, the human infant typically has 270 bones, and many bones fuse together to reach a total of 207 bones in adulthood. However, some bones aren’t even formed yet in babies, when they’re born.

Included among those bones is the eight carpals, or wrist-bones. They begin to ossify (solidify) around 2 months of age, and continue to form through the beginning of puberty.

The last wrist bone to form (the pisiform) is a sesamoid bone, which forms part of the the ulnar border (near the pinky finger as opposed to the thumb) of the wrist.

Being a sesamoid bone means that it is a bone embedded within a tendon or muscle, and most often formed in response to strain. Unlike the other wrist bones, it doesn’t contribute to the rotation of the wrist, and is not an anchor for any major tendons or muscles.

Atlas and Text-Book of Human Anatomy. Dr. Johannes Sobotta, 1914.

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Anonymous asked:

Is osteomyelitis the only disease concerning viral infections of the bone?

Osteomyelitis isn't so much about what kind of infection as the reaction to the infection that the body produces - in this case inflammation of the bone marrow (osteo - bone, myel - marrow, itis - swelling).

Viral osteomyelitis is very uncommon compared to bacterial and even fungal infections, or autoimmune reactions. While it used to be a fairly common complication (2-5%) with smallpox, today it's rarely seen outside of uterine rubella and cytomegalic inclusion disease.

However, should viral infection of the bone occur without causing osteomyelitis, arthritic complications are still common, and very rarely osteonecrosis have been found.

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General Daniel Sickles' amputated leg bones with similar cannonball to the one that hit him in 1863. Daniel Sickles' leg was removed after he was struck by a cannonball at the Battle of Gettysburg.

Prior to the Civil War, Gen. Sickles had murdered the son of Francis Scott Key (who was having an affair with his young wife), and had been put on trial, but had been acquitted.

When he was struck during the war, he was, in effect, removed from his post, but he resented that. After being removed, he ran a campaign against both Gen. George Meade and Ulysses S. Grant, which attacked them both for not allowing him back to the field.

After the war, he served as ambassador to Spain, and survived until 1914.

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Fig 1: Front side of Os Femoris (the femur bone) Fig 2: Back side of Os Femoris Fig 3: Underside of Patella, where it moves against the Os Femoris

The femur is, by most measures, the strongest bone in the tetrapod body. Its articulation with the acetebelum of the pelvis forms the freely-moving synovial hip joint, and its articulation with the tibia and patella at its distal end forms the knee joint. These joints accommodate walking, running, and jumping, which are critical activities for the survival of most tetrapods.

At the bottom of the front-facing femur (Fig 1), you can see an articular depression between the two condyles, called the patellar surface. This is where the patella rests. The deeper notch in the back of the femur (Fig 2) provides an articular surface for the many ligaments of the knee joint.

The patella's primary purpose is to provide protection to the crucial structures in the knee. The synovial joint is strong, but if it got damaged when we were still living off the land, it could mean death from an inability to farm or hunt.

Cheselden’s Plates of the Human Bones. William Cheselden, 1814 reprint.

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These recent images of the skull are topical for me as my mother was just diagnosed with Hyperostosis Frontalis this afternoon! Your blog is fantastic.

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Cool! If her skull keeps thickening, maybe she can win a harem of wildebeest or antelope! I wouldn't advise going against the bighorn sheep, though; those guys have a honeycombed "double skull" in addition to the thickened bones. By the by, for anyone who doesn't know, hyperostosis frontalis is exactly what it sounds like - "hyper": excessive, over - "osto": bone - "-sis": process, condition. And "frontalis" simply refers to the "frontal crest" - the flat-ish, "forehead" region of the frontal bone in the skull.

Put it together and you can see that the term means, roughly, "a process producing an excessive frontal bone". The condition is pretty common in post-menopausal women, and as the thickening is internal, it is not usually discovered until a CT or MRI is taken for some other condition. The cause of the thickening of the bones isn't known, but given that the majority of the people who have it are post-menopausal women, it's assumed to be hormonal.

~ Interestingly, hyperostosis frontalis used to be thought to actually be a clinically significant finding, back before CT/MRI scans made it possible to see the skull prior to death. As the finding wasn't universal, but not uncommon, in older women, pathologists thought that it went along with numerous other fatal conditions, and at times, actually used it as a "shortcut" to finding the true cause of death. Unfortunately, none of those assumptions turned out to be correct - the bone thickening on its own has no significant clinical implications (other than there may be a potential hormone imbalance in a younger person - but even this doesn't have a high correlation).

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Ecchondroma of the ilium

Chondromas are benign cartilaginous tumors, which are formed by errant chondrocytes (cartilage-creating cells) creating encapsulated lobular growths either within bones (enchondromas), or outward from the bones (ecchondromas). Ecchondromas are much more uncommon than cartilage tumors which grow from within the bone.

American Text-Book of Surgery. Edited by J. William White and William W. Keen, 1894.

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Hi, do you know what the bone splint would have been made out of? (Bone from another source...?) Can I assume the ulnar fragments and the splint would have eventually "healed" together?

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It appears that in the long bones, splints used were generally sterilized silver or steel rods. There were bone chips and marrow tissue from other bones inserted into the area of missing bone (bone grafts weren’t done before the wound was at least beginning to heal and obviously free of infection, and due to a lack of reliable antibiotics, that could take several weeks back then), and the bone typically was kept in traction for several weeks-to-months while it healed together. The rods were not generally taken out after the two ends of the long bone had healed together (they still aren’t in many cases).

Fred Albee pioneered bone graft surgery in 1915, and made it so there were more options than “let it heal together without the missing bone” (making short, misaligned limbs), or “cut that shit off!” While the bone grafting process took a lot longer to get started before people were confident infection wouldn’t occur, and wasn’t nearly as quick to heal as today’s grafts, it did allow most significantly wounded soldiers to keep their limbs. A lot of those soldiers ended up coming back to the home front and either leading younger draftees, or working in munitions factories.

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