A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

Hey, since we're talking about giving blood today - a friend of the family got in an accident yesterday due to a vagus event after a blood draw. He had never had one before. My wife gets these somewhat frequently, so:

If you've never passed out after a blood draw or injection, you should wait at least fifteen minutes after an injection or blood draw before you drive or do anything where a sudden loss of consciousness could cause you serious injury - climb a ladder, use a sharp knife, etc. If you ever have, you should wait half an hour.

Our friend is okay. He was driving below the speed limit and wearing his seatbelt when he briefly lost consciousness. His car is totaled, but he's okay.

Please be careful. I know we're all really busy, and we've all got a million places to be, but you can't tough your way through your body deciding it needs to reset itself by passing out briefly.

I also really recommend bringing a cookie or granola bar and water (or any little snack) if you're getting a blood draw so you can have that after

This is especially helpful if you had to be fasting for the test

Oh for sure.

To be clear, y'all, every place I've ever been that you give blood or get it drawn for tests recommends that you stay for 15m.

A lot of people don't do that. We're all busy, and I don't think most of us know what might happen bc if you've never had vasovagal syncope/a vagus event... you don't know how completely out of your control it is. You're busy having a normal day and then you wake up on the floor.

A friend of mine nearly had a Very Bad Day the day before yesterday.

I took that as an opportunity to remind people to take care of themselves.

That's all. :)

Wait, don’t they give you snacks as a thank you for giving blood out there??? One of the best things about giving blood is that after you get to sit in the ‘you just gave blood and we’re keeping an eye on you’ zone while you have a drink and a sweet or salty snack (or if you’re cheeky, both) before they’ll let you leave.

And don’t get me started about Germany! There they get swag bags of stuff donated by companies wanting to be seen to be supporting blood donation. I live in envy of my friend in Germany and her blood donation swag.

They do, usually, yes.

Let me underline the words "blood draws for tests," y'all.

My friend had a blood draw. He was not donating blood. He had a snack AFAIK. He still passed out.

These things can happen anyway if people rush off bc they're busy and don't wait the full 15-30m as recommended. Even if you do everything right, you can still pass out.

All I'm saying is please take your time and wait the full 15-30 minutes.

I'm not saying anybody isn't getting snacks or isn't being taken care of. This isn't an indictment of the US except inasmuch we are sometimes too busy to take care of ourselves. That's it.

I always ask them to do my left as a matter of course. I now feel lucky.

pls reblog for sample size etc

follow for more occasional useless polls :)

Hmm. If they can make this strategy work for COVID, that’ll really be something.

"People at higher risk for the most severe complications of Covid — primarily those ages 65 and older — should get a booster shot this spring."

reblogging this article because it's right here, but adding to the post that immunocompromised adults should also get spring boosters, and people can self-attest to also get a booster. if you live with or hang out with older adults/immunocompromised adults you should try to get a booster.

Look out for yourself and your community and see if you can get a booster. if you don't have insurance look up Bridge pharmacy programs that will give them for free.

" The CDC has recommended spring boosters for people age 65 and older, at least 4 months after the previous updated dose. As of 3/2/2024, only about 42.4% of adults age 65 and older had gotten an updated vaccine, and many who were vaccinated in the fall may not realize they are eligible for another dose.

In addition to the spring boosters recommended for people aged 65 and older, immunocompromised people are eligible for more frequent vaccination. The CDC states, “You can self-attest to your moderately or severely immunocompromised status, which means you do not need any documentation of your status to receive COVID-19 vaccines you might be eligible to receive.”"

---from People's CDC March 18th 2024 Weather Report

My problem is that I developed a hyperfixation on historical diseases and their transmission when I was a kid, so I was basically primed to be the angriest cunt in the world about covid. I was always going to become furious and extra-insane.

The flu never went away, so you get your flu shot and cover your coughs and sneezes.

HIV/AIDS never went away, so you use protection with sex and always use clean needles for any kind of injections.

The bubonic plague, the granddaddy of plagues itself? Also never went away! You're supposed to be careful about any interactions with wildlife, and take flea outbreaks seriously.

Covid hasn't gone away, and it probably won't. So you know what you're supposed to fucking be doing? Limiting exposure, staying home from superspreaders, wearing your masks, getting your updated vaccines, and following the safety protocols from the People's CDC.

You damn sure aren't supposed to just throw up your hands, say, "fuck it, we'll all probably get it, so who cares?" and start licking rats, fucking without condoms, and running around without a face mask.

Great news for uninsured adults in the USA who want a COVID-19 booster! It now appears that ALL CVS locations are now active participants in the Bridge Access Program. The Bridge Access Program gives out free Covid-19 vaccinations to 18+ adults who otherwise can't afford one, so if you have a CVS near you, please go get one! For others who don't have a CVS near them, please go to vaccines.gov, click on "Find Covid-19 vaccines", fill out which vaccines you prefer (you can mix different vaccines if you have to so i reccomend just marking all of them for the age groups you need), and when the next page loads mark the "Bridge Access Program Participant" option to see only locations that are Bridge Access Program participants. Hopefully, other places that aren't CVS will start participating soon, so just check back every so often to see if there are any updates. The CDC Bridge Access Program website also has more details on what locations will be participating, but only CVS is appearing as an active participant on the vaccines.gov location finder at the moment.

For anyone who doesn't know: there is currently a NEW BOOSTER available, designed to counter the XBB variant (which is circulating big time currently). So this is not only topping up your existing immunity but adapting it, much like the bivalents did for Omicron and the flu shot does every year.

And if you need another reason: