Solar eclipse shadows

There were so many flatback millipedes out after dark this evening (like, hard to avoid stepping on them) and I'm slowly getting better at shooting fluorescent creatures 🖤🩵

A Filipino engineering student named Carvey Ehren Maigue has developed new solar panels made from old fruits and vegetables. The panels are “designed to continue harvesting light even during cloudy weather. This added ability means the new panels can produce energy almost half of the time, whereas current panels only produce 15-25% of the time.” He decided to try using rotten vegetation since it was in abundance in the Philippines due to shifting weather conditions resulting from climate change. (source)

Also...PRETTY!!! Here are Maigue’s panels used in the Montreal Convention Center’s facade:

Here’s a short video with demos of how the panels work even on cloudy days and in comparison to commercial grade glass windows.

Ummm yes please! Those are gorgeous!

November 20, 1969: Apollo 12 astronaut Alan Bean holds a sample container filled with lunar soil. Pete Conrad, who took this image, can be seen in Bean’s helmet visor.

Letssss gooooooo !!!!!!!! 🥳🥳🥳🥳🥳🥳

INDIA HAS DONE IT.👑😎

India became the first nation to successfully land a spacecraft near the south pole of the FRICKING MOOON!!!!!

India creates history and this calls for a celebration.

India is on da moon!!!!!

Seeing UV colors is common for butterflies, but in some species, it is a female-only power

So, you may or may not know that many butterflies can actually see in UV light. It is very cool and I'm definitely not jealous that they get extra colors. It's helpful to them because many flowers have UV patterns on them (invisible to us) that let the butterflies know that they're a good source of food. The plants get pollinated and the butterflies get to eat. Everybody wins. This is a simulated version of what butterflies might see when they look at a flower.

Some butterflies, such as the zebra longwing pictured above, only display this trait in females. Because of this, male and female butterflies will tend to visit different types of flowers. But scientists have just recently figured out how this difference came to be, evolutionarily speaking.

Obviously many species have sexually dimorphic traits, some more prominently than others. There are also cases in which one sex develops a trait that is just... less useful than the other, like this case with the UV vision. Almost all butterflies can see in the UV spectrum, so it follows that at some point in the evolutionary line the male zebra longwing butterflies lost that particular ability. There are multiple ways that this sort of thing can happen, and the article covers them briefly, but after sequencing the genome for these butterflies they found that none of those previously seen explanations were the case.

Basically, we already know the gene that causes UV vision in butterflies. It is called the opsin gene. In zebra longtail butterflies, this gene occurs on the chromosome W, which is the female sex chromosome. That means that sometime in history, this gene just jumped from a normal chromosome onto the female-only chromosome, and has locked the male butterflies out of this ability ever since. This is the first time we have seen a gene do a jump like that, and it is pretty cool.

But anyway, appreciate the girlpower of zebra longwing butterflies getting all the UV vision, and take a look at the study! It's free to read, which is really nice to see.

Researchers made a water filtration material from egg white proteins. They're cheap to make and work a lot better than the current cheapest material. This is very cool.

This the COOLEST thing ever!!!

Maths is the art of finding cool things with hopefully no practical application, and every other field of science is the art of finding practical applications for weird cool things just to spite mathematicians

Mary Soon Lee, from Elemental Haiku: Poems to Honor the Periodic Table, Three Lines at a Time

How Long Covid Exhausts the Body

Millions of people continue to suffer from exhaustion, cognitive problems and other long-lasting symptoms after a coronavirus infection. The exact causes of the illness, known as long Covid, are not known. But new research offers clues, describing the toll the illness takes on the body and why it can be so debilitating.

Diagnosing Long Covid

Patients with severe Covid may wind up in hospitals or on ventilators until their symptoms resolve. Damage to the body from severe Covid — pneumonia, low oxygen, inflammation — typically shows up on traditional diagnostic tests.

Long Covid is different: A chronic illness with a wide variety of symptoms, many of which are not explainable using conventional lab tests. Difficulties in detecting the illness have led some doctors to dismiss patients, or to misdiagnose their symptoms as psychosomatic. But researchers looking more deeply at long Covid patients have found visible dysfunction throughout the body.

Studies estimate that perhaps 10 to 30 percent of people infected with the coronavirus may develop long-term symptoms. It’s unclear why some people develop long Covid and others don’t, but four factors appear to increase the risk: high levels of viral RNA early during an infection, the presence of certain autoantibodies, the reactivation of Epstein-Barr virus and having Type 2 diabetes.

The Immune System

“Dang, why am I always so sick?”— Messiah Rodriguez, 17

Long Covid patients appear to have disrupted immune systems compared to post-Covid patients who fully recover. Many researchers believe chronic immune dysfunction after a coronavirus infection may set off a chain of symptoms throughout the body.

One possibility is that the body is still fighting remnants of the coronavirus. Researchers found that the virus spreads widely during an initial infection, and that viral genetic material can remain embedded in tissues — in the intestines, lymph nodes and elsewhere — for many months.

Figure: Coronavirus RNA is visible in different body tissues at 500x magnification. Daniel Chertow et al., preprint via Research Square

Ongoing studies are trying to determine if these viral reservoirs cause inflammation in surrounding tissues, which could lead to brain fog, gastrointestinal problems and other symptoms.

Figure: Coronavirus components persist in one patient’s small intestine, 92 days after the start of their Covid symptoms. Christian Gaebler et al., Nature

Researchers have also found evidence that Covid may trigger a lasting and damaging autoimmune response. Studies have found surprisingly high levels of autoantibodies, which mistakenly attack a patient’s own tissues, many months after an initial infection.

A third possibility is that the initial viral infection triggers chronic inflammation, possibly by reactivating other viruses in the patient’s body that are normally dormant. The reactivation of Epstein-Barr virus, which infects most people when they are young, might help predict whether a person will develop long Covid, one study found.

Inside the intricate world of the immune system, these explanations may coexist. And just as different long Covid patients may have different symptoms, they may also have different immune problems, too. Identifying the problems that are central to each patient’s illness will be critical for guiding treatment, said Dr. Akiko Iwasaki, an immunologist at Yale.

For instance, a patient with autoantibodies might benefit from immunosuppressive medication, while a patient with remnants of the Covid virus should receive antivirals, Dr. Iwasaki said. “Depending on what each person has, the treatment would be quite different.”

The Circulatory System

“Something as simple as climbing on a ladder all of a sudden became a mountain.”— Eddie Palacios, 50

Many long Covid patients struggle with physical activity long after their initial infection, and experience a relapse of symptoms if they exercise. Initial studies suggest that dysfunction in the circulatory system might impair the flow of oxygen to muscles and other tissues, limiting aerobic capacity and causing severe fatigue.

In one study, patients with long-lasting Covid symptoms had unexpected responses to riding a bike. Despite having apparently normal hearts and lungs, their muscles were only able to extract a portion of the normal amount of oxygen from small blood vessels as they pedaled, markedly reducing their exercise capacity.

One possible culprit: Chronic inflammation may damage nerve fibers that help control circulation, a condition called small fiber neuropathy. The damaged fibers, seen in skin biopsies, are associated with dysautonomia, a malfunction of automatic functions like heart rate, breathing and digestion that is very common in long Covid patients.

Figure: Chronic inflammation in long Covid patients may damage small nerve fibers. Peter Novak et al., Annals of Neurology

These findings demonstrate that people with long Covid are suffering systemic physical problems, rather than just being anxious or out of shape, said Dr. David M. Systrom, an exercise physiologist at Brigham and Women’s Hospital who helped conduct the bike study.

“You can’t make up small fiber neuropathy by skin biopsy. That isn’t in somebody’s head,” Dr. Systrom said. “You can’t make up poor oxygen extraction to this degree. All of these are objective measures of disease.”

South African researchers found another circulation problem: Microscopic blood clots. Tiny clots that form during an initial Covid infection will typically break down naturally, but might persist in long Covid patients. These clots could block the tiny capillaries that carry oxygen to tissues throughout the body.

Figure: Platelets in the blood can become hyperactivated in Covid and long Covid patients, contributing to microclots. Etheresia Pretorius et al., Cardiovascular Diabetology

Inflammatory substances called cytokines, which are often elevated in long Covid patients, may injure the mitochondria that power the body’s cells, making them less able to use oxygen. Walls of blood vessels may also become inflamed, limiting the uptake of oxygen.

Whatever the cause, low oxygen levels may contribute to long Covid’s most common symptom, severe fatigue. Some long Covid patients meet the criteria for ME/CFS (also known as chronic fatigue syndrome), which often starts after a viral infection. Researchers have found that ME/CFS patients also suffer from a lack of oxygen triggered by circulatory problems. That puts enormous strain on the body’s metabolism and makes simple activities feel like strenuous exercise.

The Brain

“I approach a red light, my brain knows that it’s red, but it’s not reacting to the rest of my body to put my foot on the brake. Do you understand how terrifying that is?”— Samantha Lewis, 34

Even people with mild cases of Covid can experience sustained cognitive impairments, including reduced attention, memory and word-finding. Possible long-term neurological problems from Covid constitute “a major public health crisis,” according to Dr. Avindra Nath, the clinical director of the National Institute of Neurological Disorders and Stroke.

Researchers found a wide range of dysfunction in the brains of long Covid patients. Although it is unclear how often the virus directly penetrates the brain, even mild infections appear to cause significant brain inflammation, according to the researchers, who included Dr. Nath, Dr. Iwasaki and Dr. Michelle Monje, a neurologist at Stanford.

Infections may trigger the over-activation of immune cells called microglia in a way that appears similar to the process that can contribute to cognitive problems in aging and some neurodegenerative diseases.

Figure: Microglia are activated in the brain of a Covid patient, contributing to brain inflammation. Anthony Fernández-Castañeda et al., preprint via bioRxiv. Photos: Myoung-Hwa Lee

Another research group found that long Covid may significantly reduce the amount of blood that reaches the brain, a finding that has was also seen in patients with a related chronic condition, ME/CFS, before the pandemic.

The Lungs

“I couldn’t breathe. It literally felt like someone was sitting on my chest.”— Angelica Baez, 23

Shortness of breath is a frequent symptom of long Covid. But common lung tests — including chest X-rays, CT scans and functional tests — often come back normal.

Using specialized M.R.I. scans, a team of British researchers found preliminary evidence of lung damage in a small group of long Covid patients who had never been hospitalized. Detailed scans of their lung function indicated that most of the patients took up oxygen less efficiently than healthy people did, even if the structure of their lungs appeared to be normal.

The researchers cautioned that a larger group of patients will be needed to confirm the findings. If the results hold up, possible explanations for the observed shortness of breath include microclots in lung tissues or a thickening of the blood-air barrier that regulates the uptake of oxygen in the lungs.

Living With Long Covid

“It’s really not something you can push through.”— Dr. Abigail Bosk

Many hospitals now offer post-Covid clinics or recovery programs, which bring together doctors with experience treating long Covid patients. Given the number of patients, some doctors and programs have long waits for appointments. It can help to plan ahead and try multiple options.

— Survivor Corps keeps a directory of post-Covid clinics.

— Dysautonomia International offers a list of doctors with experience treating autonomic disorders commonly seen in long Covid.

— Body Politic hosts a Covid support group where thousands of long haulers share information and advice on Slack.

— The Long Covid Support Group hosts a community on Facebook.

— The Royal College of Occupational Therapists offers advice for managing post-Covid fatigue.

— An essay from Maria Farrell offers advice on how to get well, and the importance of making time to rest.

— ME Action, a group supporting people with ME/CFS, offers advice to long Covid patients on how to manage symptoms.

— Americans with long Covid may qualify for disability benefits, although without conclusive medical results, many people face roadblocks.

— Three leading researchers into long Covid often share information about the latest findings on Twitter: Dr. Amy Proal, a microbiologist at PolyBio Research Institute; Dr. David Putrino, the director of rehabilitation innovation for the Mount Sinai Health System; and Dr. Iwasaki, the Yale immunologist.

— Health Rising covers the latest research into long Covid, ME/CFS and other chronic illnesses in detail.

— Gez Medinger, a video producer, interviews some prominent researchers into long Covid on YouTube.

— A video interview with Dr. Svetlana Blitshteyn, a neurologist and the director of the Dysautonomia Clinic, offers advice for treatment and an overview of current research into autonomic disorders.

— A detailed guide to understanding, treating and living with orthostatic intolerance is available from the Johns Hopkins Children’s Center.

Source: by Josh Keller (The New York Times). Illustration by Violet Frances for Bryan Christie Design. Produced by Jonathan Corum. Additional reporting by Pam Belluck and Amanda Morris. 

Read to succeed ─ in math. Study shows how reading skill shapes more than just reading

A University at Buffalo researcher’s recent work on dyslexia has unexpectedly produced a startling discovery which clearly demonstrates how the cooperative areas of the brain responsible for reading skill are also at work during apparently unrelated activities, such as multiplication.

Though the division between literacy and math is commonly reflected in the division between the arts and sciences, the findings suggest that reading, writing and arithmetic, the foundational skills informally identified as the three Rs, might actually overlap in ways not previously imagined, let alone experimentally validated.

“These findings floored me,” said Christopher McNorgan, PhD, the paper’s author and an assistant professor in UB’s Department of Psychology. “They elevate the value and importance of literacy by showing how reading proficiency reaches across domains, guiding how we approach other tasks and solve other problems.

“Reading is everything, and saying so is more than an inspirational slogan. It’s now a definitive research conclusion.”

And it’s a conclusion that was not originally part of McNorgan’s design. He planned to exclusively explore if it was possible to identify children with dyslexia on the basis of how the brain was wired for reading.

“It seemed plausible given the work I had recently finished, which identified a biomarker for ADHD,” said McNorgan, an expert in neuroimaging and computational modeling.

Like that previous study, a novel deep learning approach that makes multiple simultaneous classifications is at the core of McNorgan’s current paper, which appears in the journal Frontiers in Computational Neuroscience.

Deep learning networks are ideal for uncovering conditional, non-linear relationships.

Where linear relationships involve one variable directly influencing another, a non-linear relationship can be slippery because changes in one area do not necessarily proportionally influence another area. But what’s challenging for traditional methods is easily handled through deep learning.

McNorgan identified dyslexia with 94% accuracy when he finished with his first data set, consisting of functional connectivity from 14 good readers and 14 poor readers engaged in a language task.

But he needed another data set to determine if his findings could be generalized. So McNorgan chose a math study, which relied on a mental multiplication task, and measured functional connectivity from the fMRI information in that second data set.

Functional connectivity, unlike what the name might imply, is a dynamic description of how the brain is virtually wired from moment to moment. Don’t think in terms of the physical wires used in a network, but instead of how those wires are used throughout the day. When you’re working, your laptop is sending a document to your printer. Later in the day, your laptop might be streaming a movie to your television. How those wires are used depends on whether you’re working or relaxing. Functional connectivity changes according to the immediate task.

The brain dynamically rewires itself according to the task all the time. Imagine reading a list of restaurant specials while standing only a few steps away from the menu board nailed to the wall. The visual cortex is working whenever you’re looking at something, but because you’re reading, the visual cortex works with, or is wired to, at least for the moment, the auditory cortex.

Pointing to one of the items on the board, you accidentally knock it from the wall. When you reach out to catch it, your brain wiring changes. You’re no longer reading, but trying to catch a falling object, and your visual cortex now works with the pre-motor cortex to guide your hand.

Different tasks, different wiring; or, as McNorgan explains, different functional networks.

In the two data sets McNorgan used, participants were engaged in different tasks: language and math. Yet in each case, the connectivity fingerprint was the same, and he was able to identify dyslexia with 94% accuracy whether testing against the reading group or the math group.

It was a whim, he said, to see how well his model distinguished good readers from poor readers – or from participants who weren’t reading at all. Seeing the accuracy, and the similarity, changed the direction of the paper McNorgan intended.

Yes, he could identify dyslexia. But it became obvious that the brain’s wiring for reading was also present for math.

Different task. Same functional networks.

“The brain should be dynamically wiring itself in a way that’s specifically relevant to doing math because of the multiplication problem in the second data set, but there’s clear evidence of the dynamic configuration of the reading network showing up in the math task,” McNorgan says.

He says it’s the sort of finding that strengthens the already strong case for supporting literacy.

“These results show that the way our brain is wired for reading is actually influencing how the brain functions for math,” he said. “That says your reading skill is going to affect how you tackle problems in other domains, and helps us better understand children with learning difficulties in both reading and math.”

As the line between cognitive domains becomes more blurred, McNorgan wonders what other domains the reading network is actually guiding.

“I’ve looked at two domains which couldn’t be farther afield,” he said. “If the brain is showing that its wiring for reading is showing up in mental multiplication, what else might it be contributing toward?” That’s an open question, for now, according to McNorgan.

“What I do know because of this research is that an educational emphasis on reading means much more than improving reading skill,” he said. “These findings suggest that learning how to read shapes so much more.”

Things That Weren't Invented/Discovered By White People: Scientific and Mathematical Theories Edition